People make mistakes.
It's why they put rubbers on the ends of pencils.
人人都会犯错
screw (sth) up 就是犯错；搞糟；弄坏的意思
比如：
I totally screwed up the chemistry exam.
化学考试被我彻底考砸了。
Just don't screw up this time.
这次可别搞砸了。
不过有的时候被 screwed up 是某个人
screw sb up 的意思是指
使某人焦虑不安；令某人很难过；使某人精神崩溃
It really screwed him up when he saw his friend get killed.
看到自己的朋友遇难，他伤心欲绝。
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